This guide was developed to help investigators in the HMO Research Network organize and conduct cluster randomized trials (CRTs). It highlights key planning and operational challenges in multi-site CRTs and offers recommendations for how those challenges should be addressed. Content areas include general considerations and rationale, defining clusters and issues relating to cluster randomization, sample size, informed consent, blinding and other topic requiring special consideration in a CRT. Click here to download.
From the HMO Research Network Collaboration Toolkit. www.hmoresearchnetwork.org
